Genetic variability at HPA axis in major depression and clinical response to antidepressant treatment

Volume: 104, Issue: 1-3, Pages: 83 - 90
Published: Dec 1, 2007
Abstract
Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis has been observed in major depression. Normalization of HPA axis has been suggested to play a role in the mechanisms of action of antidepressants. Our aim was to investigate the influence of genetic variants in CRHR1, CRHR2, CRH-BP and FKBP5 genes on both the vulnerability for depression and the response to antidepressant treatment.The sample consisted of 159 depressive outpatients...
Paper Details
Title
Genetic variability at HPA axis in major depression and clinical response to antidepressant treatment
Published Date
Dec 1, 2007
Volume
104
Issue
1-3
Pages
83 - 90
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