Clonal evolution in breast cancer revealed by single nucleus genome sequencing
Abstract
Sequencing studies of breast tumour cohorts have identified many prevalent mutations, but provide limited insight into the genomic diversity within tumours. Here we developed a whole-genome and exome single cell sequencing approach called nuc-seq that uses G2/M nuclei to achieve 91% mean coverage breadth. We applied this method to sequence single normal and tumour nuclei from an oestrogen-receptor-positive (ER(+)) breast cancer and a...
Paper Details
Title
Clonal evolution in breast cancer revealed by single nucleus genome sequencing
Published Date
Jul 30, 2014
Journal
Volume
512
Issue
7513
Pages
155 - 160
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