Evidence that OGG1 glycosylase protects neurons against oxidative DNA damage and cell death under ischemic conditions

Volume: 31, Issue: 2, Pages: 680 - 692
Published: Feb 1, 2011
Abstract
7,8-Dihydro-8-oxoguanine DNA glycosylase (OGG1) is a major DNA glycosylase involved in base-excision repair (BER) of oxidative DNA damage to nuclear and mitochondrial DNA (mtDNA). We used OGG1-deficient (OGG1−/−) mice to examine the possible roles of OGG1 in the vulnerability of neurons to ischemic and oxidative stress. After exposure of cultured neurons to oxidative and metabolic stress levels of OGG1 in the nucleus were elevated and...
Paper Details
Title
Evidence that OGG1 glycosylase protects neurons against oxidative DNA damage and cell death under ischemic conditions
Published Date
Feb 1, 2011
Volume
31
Issue
2
Pages
680 - 692
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.