Testing for HER2-positive breast cancer: a systematic review and cost-effectiveness analysis

Background: Testing to determine HER2 status has come into focus since the approval of trastuzumab (Herceptin) for the treatment of HER2-positive breast cancer. We compared the cost-effectiveness of various strategies used to test HER2 status, an important first step toward evaluating the overall cost-effectiveness of trastuzumab therapy. Methods: We performed a systematic review of studies that evaluated concordance between...