Telomeres, chromosome instability and cancer
Abstract
Telomeres are composed of repetitive G-rich sequence and an abundance of associated proteins that together form a dynamic cap that protects chromosome ends and allows them to be distinguished from deleterious DSBs. Telomere-associated proteins also function to regulate telomerase, the ribonucleoprtotein responsible for addition of the species-specific terminal repeat sequence. Loss of telomere function is an important mechanism for the...
Paper Details
Title
Telomeres, chromosome instability and cancer
Published Date
Apr 28, 2006
Journal
Volume
34
Issue
8
Pages
2408 - 2417
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History