Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Abstract
Autophagy is an intracellular bulk degradation process through which a portion of the cytoplasm is delivered to lysosomes to be degraded. Although the primary role of autophagy in many organisms is in adaptation to starvation, autophagy is also thought to be important for normal turnover of cytoplasmic contents, particularly in quiescent cells such as neurons. Autophagy may have a protective role against the development of a number of...
Paper Details
Title
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Published Date
Apr 19, 2006
Journal
Volume
441
Issue
7095
Pages
885 - 889
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Notes
History