PKA enhances the acute insulin response leading to the restoration of glucose control
Abstract
Diabetes arises from insufficient insulin secretion and failure of the β-cell mass to persist and expand. These deficits can be treated with ligands to Gs-coupled G-protein-coupled receptors that raise β-cell cAMP. Here we studied the therapeutic potential of β-cell cAMP-dependent protein kinase (PKA) activity in restoring glucose control using β-caPKA mice. PKA activity enhanced the acute insulin response (AIR) to glucose, which is a primary...
Paper Details
Title
PKA enhances the acute insulin response leading to the restoration of glucose control
Published Date
May 1, 2015
Journal
Volume
64
Issue
5
Pages
1688 - 1697
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