Timing of futility analyses for ‘proof of concept’ trials
Abstract
‘Proof of concept’ (PoC) trials often are carried out to determine if a treatment is biologically active or inactive. If the predictive probability of rejecting a null hypothesis of no treatment effect on completion of the trial calculated using information accumulated before trial completion is sufficiently low, then the trial could be terminated and resources redirected more productively. If the predictive probability is high, some time might...
Paper Details
Title
Timing of futility analyses for ‘proof of concept’ trials
Published Date
Jan 1, 2005
Journal
Volume
24
Issue
12
Pages
1815 - 1835
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