Substantial Shared Genetic Influences on Schizophrenia and Event-Related Potentials

Several components of event-related potentials--P50 suppression, P300 amplitude and latency, and mismatch negativity--have been proposed as potential endophenotypes for schizophrenia on the basis of family studies. The present study used a twin design to estimate the extent of genetic overlap between these indices and the liability to schizophrenia.The authors measured mismatch negativity, P300, and P50 suppression in 16 monozygotic twin pairs...