Original paper
Programmable Removal of Bacterial Strains by Use of Genome-Targeting CRISPR-Cas Systems
Abstract
CRISPR (clustered regularly interspaced short palindromic repeats)-Cas (CRISPR-associated) systems in bacteria and archaea employ CRISPR RNAs to specifically recognize the complementary DNA of foreign invaders, leading to sequence-specific cleavage or degradation of the target DNA. Recent work has shown that the accidental or intentional targeting of the bacterial genome is cytotoxic and can lead to cell death. Here, we have demonstrated that...
Paper Details
Title
Programmable Removal of Bacterial Strains by Use of Genome-Targeting CRISPR-Cas Systems
Published Date
Feb 28, 2014
Journal
Volume
5
Issue
1
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Notes
History