Using Targeted Chromatin Regulators to Engineer Combinatorial and Spatial Transcriptional Regulation
Abstract
The transcription of genomic information in eukaryotes is regulated in large part by chromatin. How a diverse array of chromatin regulator (CR) proteins with different functions and genomic localization patterns coordinates chromatin activity to control transcription remains unclear. Here, we take a synthetic biology approach to decipher the complexity of chromatin regulation by studying emergent transcriptional behaviors from engineered...
Paper Details
Title
Using Targeted Chromatin Regulators to Engineer Combinatorial and Spatial Transcriptional Regulation
Published Date
Jul 1, 2014
Journal
Volume
158
Issue
1
Pages
110 - 120
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