Original paper
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
Abstract
Systematic interrogation of gene function requires the ability to perturb gene expression in a robust and generalizable manner. Here we describe structure-guided engineering of a CRISPR-Cas9 complex to mediate efficient transcriptional activation at endogenous genomic loci. We used these engineered Cas9 activation complexes to investigate single-guide RNA (sgRNA) targeting rules for effective transcriptional activation, to demonstrate...
Paper Details
Title
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
Published Date
Dec 10, 2014
Journal
Volume
517
Issue
7536
Pages
583 - 588
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Notes
History