Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison

Psychotic disorders, such as schizophrenia, are associated with neuroanatomical abnormalities, but whether these predate the onset of symptoms or develop progressively over the course of illness is unclear. We investigated this issue with MRI to study people with prodromal symptoms who are at ultra high-risk for the development of psychosis.We did two comparisons, cross-sectional and longitudinal. For the cross-sectional comparison, 75 people...