Original paper
Common Variation in SIM1 Is Reproducibly Associated With BMI in Pi ma Indians
Abstract
OBJECTIVE Haploinsufficiency of SIM1 is a cause of rare monogenic obesity. To assess the role of SIM1 in polygenic obesity, this gene was analyzed in the Pima Indian population, which has a high prevalence of obesity. RESEARCH DESIGN AND METHODS SIM1 was sequenced in 96 individuals. Variants (n = 46) were genotyped in a population-based sample of 3,250 full-heritage Pima Indians and in a separate replication sample of 2,944 predominately...
Paper Details
Title
Common Variation in SIM1 Is Reproducibly Associated With BMI in Pi ma Indians
Published Date
Apr 28, 2009
Journal
Volume
58
Issue
7
Pages
1682 - 1689
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Notes
History