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Major lipids, apolipoproteins, and risk of vascular disease.

Published on Nov 11, 2009in JAMA51.27
· DOI :10.1001/jama.2009.1619
Emanuele Di Angelantonio54
Estimated H-index: 54
,
Nadeem Sarwar29
Estimated H-index: 29
+ 10 AuthorsJohn Danesh101
Estimated H-index: 101
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Abstract
CONTEXT: Associations of major lipids and apolipoproteins with the risk of vascular disease have not been reliably quantified. OBJECTIVE: To assess major lipids and apolipoproteins in vascular risk. DESIGN, SETTING, AND PARTICIPANTS: Individual records were supplied on 302,430 people without initial vascular disease from 68 long-term prospective studies, mostly in Europe and North America. During 2.79 million person-years of follow-up, there were 8857 nonfatal myocardial infarctions, 3928 coronary heart disease [CHD] deaths, 2534 ischemic strokes, 513 hemorrhagic strokes, and 2536 unclassified strokes. MAIN OUTCOME MEASURES: Hazard ratios (HRs), adjusted for several conventional factors, were calculated for 1-SD higher values: 0.52 log(e) triglyceride, 15 mg/dL high-density lipoprotein cholesterol (HDL-C), 43 mg/dL non-HDL-C, 29 mg/dL apolipoprotein AI, 29 mg/dL apolipoprotein B, and 33 mg/dL directly measured low-density lipoprotein cholesterol (LDL-C). Within-study regression analyses were adjusted for within-person variation and combined using meta-analysis. RESULTS: The rates of CHD per 1000 person-years in the bottom and top thirds of baseline lipid distributions, respectively, were 2.6 and 6.2 with triglyceride, 6.4 and 2.4 with HDL-C, and 2.3 and 6.7 with non-HDL-C. Adjusted HRs for CHD were 0.99 (95% CI, 0.94-1.05) with triglyceride, 0.78 (95% CI, 0.74-0.82) with HDL-C, and 1.50 (95% CI, 1.39-1.61) with non-HDL-C. Hazard ratios were at least as strong in participants who did not fast as in those who did. The HR for CHD was 0.35 (95% CI, 0.30-0.42) with a combination of 80 mg/dL lower non-HDL-C and 15 mg/dL higher HDL-C. For the subset with apolipoproteins or directly measured LDL-C, HRs were 1.50 (95% CI, 1.38-1.62) with the ratio non-HDL-C/HDL-C, 1.49 (95% CI, 1.39-1.60) with the ratio apo B/apo AI, 1.42 (95% CI, 1.06-1.91) with non-HDL-C, and 1.38 (95% CI, 1.09-1.73) with directly measured LDL-C. Hazard ratios for ischemic stroke were 1.02 (95% CI, 0.94-1.11) with triglyceride, 0.93 (95% CI, 0.84-1.02) with HDL-C, and 1.12 (95% CI, 1.04-1.20) with non-HDL-C. CONCLUSION: Lipid assessment in vascular disease can be simplified by measurement of either total and HDL cholesterol levels or apolipoproteins without the need to fast and without regard to triglyceride.
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Published on Dec 1, 2019in Lipids in Health and Disease2.65
Hao-Yu Wang (PRC: China Medical University (PRC)), Wenrui Shi (PRC: China Medical University (PRC))+ 3 AuthorsYingxian Sun22
Estimated H-index: 22
(PRC: China Medical University (PRC))
Background Monocyte to high-density lipoprotein cholesterol ratio (MHR) is a recently emerged measure of inflammation and oxidative stress and has been used to predict multiple cardiovascular abnormalities, but data relative to ischemic stroke are lacking. The goal of this study was to estimate the associations of MHR and prevalent ischemic stroke among a large cohort of general Chinese population.
Published on Apr 15, 2019in Cardiovascular Diabetology5.95
Xiaofeng Ye1
Estimated H-index: 1
(HUST: Huazhong University of Science and Technology),
Wen Kong7
Estimated H-index: 7
(HUST: Huazhong University of Science and Technology)
+ 1 AuthorsLulu Chen16
Estimated H-index: 16
(HUST: Huazhong University of Science and Technology)
Objective The importance of triglycerides (TG) level as a risk factor for cardiovascular diseases (CVD) has been extensively investigated in the general population; however, their relationship in patients with type 2 diabetes mellitus (T2DM) is uncertain. We aimed to assess the association of TG with CVD in T2DM individuals.
Published on Dec 1, 2019in Environment International7.94
Ang Li1
Estimated H-index: 1
(Peking Union Medical College),
Lu Pei2
Estimated H-index: 2
(Peking Union Medical College)
+ 4 AuthorsQun Xu15
Estimated H-index: 15
(Peking Union Medical College)
Abstract Background Little information exists on the lipidemic effects of ozone exposure. Few studies have focused on the different patterns of the association among older adults population, and little attention has been given to comprehensive lipid indices when evaluating the effect of O3 exposure on the metabolism. Methods We conducted a longitudinal study involving 201 older adults in Beijing, China between 2016 and 2018. A mixed regression model was applied with random effects to investigate...
Published on Dec 1, 2019in Arthritis Research & Therapy4.15
Helena Tydén8
Estimated H-index: 8
(Lund University),
Christian Lood17
Estimated H-index: 17
(Lund University)
+ 6 AuthorsAnders Bengtsson39
Estimated H-index: 39
(Lund University)
Apolipoprotein M (apoM) is a 25-kDa apolipoprotein present in 5% of high-density lipoprotein (HDL) particles. It is suggested to be anti-atherogenic and to play a key role in sustaining endothelial barrier integrity. SLE patients have increased cardiovascular disease risk, and we aimed to investigate if apoM levels reflect endothelial function in SLE. Since apoM plasma levels decrease during inflammatory conditions, our aim was also to determine the impact of SLE disease activity on apoM plasma ...
Published on Dec 1, 2019in Lipids in Health and Disease2.65
Lei Zhang4
Estimated H-index: 4
(Henan University),
Qilin Wan3
Estimated H-index: 3
(Henan University)
+ 9 AuthorsXiaoming Zhong4
Estimated H-index: 4
(Henan University)
Elevated serum uric acid is commonly associated with high triglyceride. However, the relation of triglyceride and hyperuricemia in different gender and age groups is currently not well understood. This study aimed to evaluate age- and gender-related association of high triglyceride with hyperuricemia in a subgroup of Chinese population. We retrospectively analyzed physical examination data of 24,438 subjects (12,557 men and 11,881 women) in Kaifeng, China. The alanine aminotransferase, γ-glutamy...
Published on Jan 8, 2019in Lipids in Health and Disease2.65
Jia Zheng1
Estimated H-index: 1
(PRC: China Medical University (PRC)),
Zhaoqing Sun19
Estimated H-index: 19
(PRC: China Medical University (PRC))
+ 5 AuthorsLiqiang Zheng21
Estimated H-index: 21
(PRC: China Medical University (PRC))
Background Studies have shown that non-traditional lipid profiles have a better association with stroke than traditional blood lipids in clinical applications, other studies have drawn different conclusions.
Published on Dec 1, 2019in Cardiovascular Diabetology5.95
Jean-Charles Fruchart111
Estimated H-index: 111
,
Raul D. Santos41
Estimated H-index: 41
(USP: University of São Paulo)
+ 52 AuthorsJean-Pierre Després110
Estimated H-index: 110
(Laval University)
In the era of precision medicine, treatments that target specific modifiable characteristics of high-risk patients have the potential to lower further the residual risk of atherosclerotic cardiovascular events. Correction of atherogenic dyslipidemia, however, remains a major unmet clinical need. Elevated plasma triglycerides, with or without low levels of high-density lipoprotein cholesterol (HDL-C), offer a key modifiable component of this common dyslipidemia, especially in insulin resistant co...
Published on Feb 18, 2019in Journal of Orthopaedic Surgery and Research1.91
Xuan Wu1
Estimated H-index: 1
(SDU: Shandong University),
Yunpeng Zhang6
Estimated H-index: 6
(SDU: Shandong University)
+ 4 AuthorsXin Xu6
Estimated H-index: 6
(SDU: Shandong University)
Background Type 2 diabetes mellitus (T2DM) and hyperlipidemia are negatively related to bone regeneration. The aim of this study was to evaluate the effect of high-fat and high-glucose microenvironment on bone regeneration and to detect the expression of runt-related transcription factor 2 (Runx2) and transcriptional co-activator with PDZ-binding domain (TAZ) during this process.
Published on Apr 17, 2019in Scientific Reports4.01
Hassan Melhem (University of Bern), Sampada Kallol2
Estimated H-index: 2
(University of Bern)
+ 7 AuthorsChristiane Albrecht16
Estimated H-index: 16
(University of Bern)
High levels of atherogenic lipids in pregnancy are associated with health complications for the mother, the fetus and the newborn. As endocrine secretory tissue, the human placenta releases apolipoproteins (apos), particularly apoA1 and apoE. However, the magnitude and the directionality of the apo secretions remain unknown. We aimed to 1) determine the amount and orientation (apical-maternal versus basal-fetal) of placentally secreted apoA1 and apoE using human perfused placenta and primary tro...
Published on Jan 22, 2019in Lipids in Health and Disease2.65
Tian-li Xia5
Estimated H-index: 5
(Sichuan University),
Yi-ming Li1
Estimated H-index: 1
(Sichuan University)
+ 9 AuthorsYing Peng18
Estimated H-index: 18
(Sichuan University)
Background The role of triglyceride (TG) in secondary prevention of patients with coronary artery disease (CAD) was debated. In the present study, we assessed the association between admission TG levels and long-term mortality risk in CAD patients.