mTOR Signaling in Growth Control and Disease
Abstract
The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis. The pathway regulates many major cellular processes and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration. Here, we review recent advances in our understanding of the mTOR pathway and its role in health,...
Paper Details
Title
mTOR Signaling in Growth Control and Disease
Published Date
Apr 1, 2012
Journal
Volume
149
Issue
2
Pages
274 - 293
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