Determining the Limits of the Evolutionary Potential of an Antibiotic Resistance Gene

Volume: 20, Issue: 4, Pages: 653 - 659
Published: Apr 1, 2003
Abstract
The AAC(6') enzymes inactivate aminoglycoside antibiotics by acetylating their substrates at the 6' position. Based on functional similarity and size similarity, the AAC(6') enzymes have been considered to be members of a single family. Our phylogenetic analysis shows that the AAC(6') enzymes instead belong to three unrelated families that we now designate as [A], [B], and [C] and that aminoglycoside acetylation at the 6' position has evolved...
Paper Details
Title
Determining the Limits of the Evolutionary Potential of an Antibiotic Resistance Gene
Published Date
Apr 1, 2003
Volume
20
Issue
4
Pages
653 - 659
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