Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells
Abstract
The continuous renewal of human epidermis is sustained by stem cells contained in the epidermal basal layer and in hair follicles. Cultured keratinocyte stem cells, known as holoclones, generate sheets of epithelium used to restore severe skin, mucosal and corneal defects. Mutations in genes encoding the basement membrane component laminin 5 (LAM5) cause junctional epidermolysis bullosa (JEB), a devastating and often fatal skin adhesion...
Paper Details
Title
Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells
Published Date
Nov 19, 2006
Journal
Volume
12
Issue
12
Pages
1397 - 1402
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Notes
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