Genomic deletions and precise removal of transposable elements mediated by short identical DNA segments in primates
Abstract
Insertion of transposable elements is a major cause of genomic expansion in eukaryotes. Less is understood, however, about mechanisms underlying contraction of genomes. In this study, we show that retroelements can, in rare cases, be precisely deleted from primate genomes, most likely via recombination between 10- to 20-bp target site duplications (TSDs) flanking the retroelement. The deleted loci are indistinguishable from pre-integration...
Paper Details
Title
Genomic deletions and precise removal of transposable elements mediated by short identical DNA segments in primates
Published Date
Sep 1, 2005
Journal
Volume
15
Issue
9
Pages
1243 - 1249
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