Treg Vaccination in Autoimmune Type 1 Diabetes
Abstract
Foxp3+ regulatory T (Treg) cells are critical contributors to the establishment and maintenance of immunological self-tolerance. Autoimmune type 1 diabetes (T1D) is characterized by the loss of self-tolerance to the insulin-producing β cells in the pancreas and the destruction of β cells, resulting in the development of chronic hyperglycemia at diagnosis. The application of strong-agonistic T-cell receptor ligands provided under subimmunogenic...
Paper Details
Title
Treg Vaccination in Autoimmune Type 1 Diabetes
Published Date
Aug 20, 2013
Journal
Volume
28
Issue
1
Pages
7 - 16
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