Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation
Abstract
Blood-brain barrier disruption, microglial activation and neurodegeneration are hallmarks of multiple sclerosis. However, the initial triggers that activate innate immune responses and their role in axonal damage remain unknown. Here we show that the blood protein fibrinogen induces rapid microglial responses toward the vasculature and is required for axonal damage in neuroinflammation. Using in vivo two-photon microscopy, we demonstrate that...
Paper Details
Title
Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation
Published Date
Nov 27, 2012
Journal
Volume
3
Issue
1
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