Childhood maltreatment and differential treatment response and recurrence in adult major depressive disorder.

A substantial number of patients with major depressive disorder (MDD) do not respond to treatment, and recurrence rates remain high. The purpose of this study was to examine a history of severe childhood abuse as a moderator of response following a 16-week acute treatment trial, and of recurrence over a 12-month follow-up.Participants included 203 adult outpatients with MDD (129 women; age 18-60). The design was a 16-week single-center...