Original paper
DNMT1-interacting RNAs block gene-specific DNA methylation
Abstract
DNA methylation was first described almost a century ago; however, the rules governing its establishment and maintenance remain elusive. Here we present data demonstrating that active transcription regulates levels of genomic methylation. We identify a novel RNA arising from the CEBPA gene locus that is critical in regulating the local DNA methylation profile. This RNA binds to DNMT1 and prevents CEBPA gene locus methylation. Deep sequencing of...
Paper Details
Title
DNMT1-interacting RNAs block gene-specific DNA methylation
Published Date
Oct 9, 2013
Journal
Volume
503
Issue
7476
Pages
371 - 376
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Notes
History