EGb-761 prevents ultraviolet B-induced photoaging via inactivation of mitogen-activated protein kinases and proinflammatory cytokine expression

Background EGb-761 is an antioxidant and anticarcinogen; however, its role as a photoprotector remains unknown. Objective To determine whether EGb-761 photoprotects human dermal fibroblasts and BALB/c mice skin against ultraviolet B (UVB) light irradiation. Methods To simulate chronic photodamage, shaved BALB/c mice were exposed to UVB irradiation (90 mJ/cm2) thrice weekly for 3 months. EGb-761 (2 mg/cm2) was topically applied 1 h before...