Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease
Abstract
We employ the CRISPR-Cas system of Streptococcus pyogenes as programmable RNA-guided endonucleases (RGENs) to cleave DNA in a targeted manner for genome editing in human cells. We show that complexes of the Cas9 protein and artificial chimeric RNAs efficiently cleave two genomic sites and induce indels with frequencies of up to...
Paper Details
Title
Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease
Published Date
Jan 29, 2013
Journal
Volume
31
Issue
3
Pages
230 - 232
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Notes
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