Synthesis of Perhydrofuro[2,3‐b]furans from Isopentenyl Alcohol through Carbonyl‐Ene and Wacker‐Type Reactions

A range of 2‐substituted perhydrofuro[2,3‐ b ]furans have been synthesized in a stereoselective manner through a sequence involving the Lewis‐acid catalyzed carbonyl‐ene reaction of a protected isopentenyl alcohol with a variety of enophiles, deprotection of the corresponding monoprotected diols, and palladium‐catalyzed intramolecular acetalization under Wacker‐type reaction...