Aging and cancer in transgenic and mutant mice

Mutant and genetically modified animal models, which are characterized by shortening or extension of the life span, give a unique possibility to evaluate the role of aging genes in mechanisms of carcinogenesis. Transgenic and null mutant ("knockout") animal models also offer an important opportunity to identify and study both carcinogens and chemopreventive agents. The analysis of the available data on transgenic and mutant mice has shown that...