Whole-Exome Sequencing of Metastatic Cancer and Biomarkers of Treatment Response

Himisha Beltran; Kenneth Eng; Juan Miguel Mosquera; Alexandros Sigaras; Alessandro Romanel; Hanna Rennert; Myriam Kossai; Chantal Pauli; Bishoy Faltas; Jacqueline Fontugne; Olivier Elemento; Mark A. Rubin

doi:https://doi.org/10.1001/jamaoncol.2015.1313

doi.org/10.1001/jamaoncol.2015.1313

Whole-Exome Sequencing of Metastatic Cancer and Biomarkers of Treatment Response

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..., Mark A. Rubin

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JAMA Oncology28.40

Volume: 1, Issue: 4, Pages: 466 - 466

Published: Jul 1, 2015

Abstract

Understanding molecular mechanisms of response and resistance to anticancer therapies requires prospective patient follow-up and clinical and functional validation of both common and low-frequency mutations. We describe a whole-exome sequencing (WES) precision medicine trial focused on patients with advanced cancer.To understand how WES data affect therapeutic decision making in patients with advanced cancer and to identify novel biomarkers of...

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Paper Details

Title

Whole-Exome Sequencing of Metastatic Cancer and Biomarkers of Treatment Response

DOI

doi.org/10.1001/jamaoncol.2015.1313

Published Date

Jul 1, 2015

Journal

JAMA Oncology

Volume

1

Issue

4

Pages

466 - 466

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