Neuroprotection associated with alternative splicing of NMDA receptors in rat cortical neurons
Abstract
Exposure of cultured cortical neurons to elevated extracellular K(+) concentrations (25 mM) induces membrane depolarization and an increase in action-potential firing. Long-term high K(+) treatment was associated with an increased neuronal cell death. In surviving neurons, multiple changes occurred in the proportion of individual NMDA receptor subunit 1 (NR1) splice variant mRNA expression, whereas the overall expression of NR1, NR2A and NR2B...
Paper Details
Title
Neuroprotection associated with alternative splicing of NMDA receptors in rat cortical neurons
Published Date
Mar 1, 2006
Volume
147
Issue
6
Pages
622 - 633
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