Anti-Inflammatory, Antiproliferative, and Radical-Scavenging Activities of Tolfenamic Acid and Its Metal Complexes

magnified image Some new complexes of tolfenamic acid (=2‐[(2‐methyl‐3‐chlorophenyl)amino]benzoic acid; Htolf) with potentially interesting biological activities are described. The complexes [Mn(tolf) 2 (H 2 O) 2 ], [Co(tolf) 2 (H 2 O) 2 ], [Ni(tolf 2 (H 2 O) 2 ], [Cu(tolf) 2 (H 2 O)] 2 , and [Zn(tolf) 2 (H 2 O)] were prepared by the reaction of tolfenamic acid, a potent anti‐inflammatory drug, with metal salts. The radical‐scavenging activities...