Phenotypic Characterization of Insulin-Resistant and Insulin-Sensitive Obesity

Whereas insulin resistance and obesity coexist, some obese individuals remain insulin sensitive.We examined phenotypic and metabolic factors associated with insulin sensitivity in both muscle and liver in obese individuals.Sixty-four nondiabetic obese adults (29 males) underwent hyperinsulinemic (15 and 80 mU/m(2) · min)-euglycemic clamps with deuterated glucose. Top tertile subjects for glucose infusion rate during the high-dose insulin clamp...