The Mutant Plasmacytoma Cell Line S107 Allows the Identification of Distinct Pathways Leading to NF-κB Activation

Studies on the mechanisms of inducible and constitutive activity of NF-κB transcription factors have been hampered by the lack of appropriate mutant cell lines. We have analyzed the defect in the murine S107 plasmacytoma cell line, which was previously found to lack both constitutive and inducible NF-κB activity. Our analysis shows that these cells bear a specific defect that interferes with NF-κB induction by many diverse stimuli, such as...