Potential novel inhibitors of trypanosomatid phosphoglycerate mutases through ligand-based and structure-based in silico approaches

Background & Hypothesis: The parasitic protozoa from the order Trypanosomatida relies exclusively on glycolysis for its survival in the mammalian hosts. As a corollary, the enzymes in this pathway have been recognised as chemotherapeutic targets. Phosphoglycerate mutase (iPGAM), which is the seventh enzyme in the pathway, is of particular interest because it possesses no structural and biochemical relationship with the corresponding enzyme in...