Importance of proper scaling of aerobic power when relating to cardiometabolic risk factors in children

Published on Sep 1, 2011in Annals of Human Biology1.588
· DOI :10.3109/03014460.2011.598561
Robert G. McMurray46
Estimated H-index: 46
(UNC: University of North Carolina at Chapel Hill),
Peter A. Hosick5
Estimated H-index: 5
(UNC: University of North Carolina at Chapel Hill),
Anna Bugge20
Estimated H-index: 20
(University of Southern Denmark)
Background: The relationship between cardiometabolic risk factors (CMRF) and aerobic power (VO2max) scaled as mL O2 per kilogram body mass is controversial because mass includes both fat and fat-free mass, and fat mass is independently associated with the CMRF.Aim: To examine common units used to scale VO2max and their relationships to mean blood pressure (MBP), total cholesterol (TC), HDL cholesterol, triglycerides (TG), insulin resistance (HOMA-IR) and cumulative risk score (z-score).Subjects: 1784, 8–18 year-old youths, 938 girls and 886 boys.Methods: Fasting blood samples were obtained. VO2max was estimated in mL/min from cycle ergometry and scaled to body mass (kg), fat free mass (kgFFM), body surface area (m2), height (cm) and allometric (mL/kg0.67/min).Results: Unadjusted correlations between CMRF and many of the scaled VO2max units were significant (p < 0.0001), especially for MBP, HOMA-IR, HDL and z-score, with lower correlations for TC and TG. After adjusting for ancestry, sex, height and body f...
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