Transient Receptor Potential Channels as Drug Targets: From the Science of Basic Research to the Art of Medicine

Volume: 66, Issue: 3, Pages: 676 - 814
Published: Jul 1, 2014
Abstract
The large Trp gene family encodes transient receptor potential (TRP) proteins that form novel cation-selective ion channels. In mammals, 28 Trp channel genes have been identified. TRP proteins exhibit diverse permeation and gating properties and are involved in a plethora of physiologic functions with a strong impact on cellular sensing and signaling pathways. Indeed, mutations in human genes encoding TRP channels, the so-called "TRP...
Paper Details
Title
Transient Receptor Potential Channels as Drug Targets: From the Science of Basic Research to the Art of Medicine
Published Date
Jul 1, 2014
Volume
66
Issue
3
Pages
676 - 814
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