Enhanced Enteral Bioavailability of Vancomycin Using Water‐in‐Oil‐in‐Water Multiple Emulsion Incorporating Highly Purified Unsaturated Fatty Acid

The aim of this study was to evaluate the potential of an emulsion incorporating unsaturated fatty acids to improve the mucosal absorption of poorly absorbed drugs from rat intestinal loops in situ, using a water-in-oil-in-water (W/O/W) multiple emulsion. Vancomycin hydrochloride (VCM) was used as a model drug with low oral bioavailability. The entrapment efficiency of VCM in the emulsion was approximately 60% and remained constant over storage...