Problems with GH assays and strategies toward standardization

Disorders affecting GH secretion – either GH deficiency or GH excess (acromegaly) – are biochemically defined through peak or nadir concentrations of human GH in response to dynamic tests. Immunoassays employing polyclonal or monoclonal antibodies are routinely used for the analysis of GH concentrations, and many different assays are available on the market today. Unfortunately, the actual value reported for the GH concentration in a specific...