Multifactorial Approach to Predicting Resistance to Anthracyclines
Abstract
Validated biomarkers predictive of response/resistance to anthracyclines in breast cancer are currently lacking. The neoadjuvant Trial of Principle (TOP) study, in which patients with estrogen receptor (ER) -negative tumors were treated with anthracycline (epirubicin) monotherapy, was specifically designed to evaluate the predictive value of topoisomerase II-α (TOP2A) and develop a gene expression signature to identify those patients who do not...
Paper Details
Title
Multifactorial Approach to Predicting Resistance to Anthracyclines
Published Date
Apr 20, 2011
Journal
Volume
29
Issue
12
Pages
1578 - 1586
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