D-Glucosamine supplementation extends life span of nematodes and of ageing mice
Abstract
D-Glucosamine (GlcN) is a freely available and commonly used dietary supplement potentially promoting cartilage health in humans, which also acts as an inhibitor of glycolysis. Here we show that GlcN, independent of the hexosamine pathway, extends Caenorhabditis elegans life span by impairing glucose metabolism that activates AMP-activated protein kinase (AMPK/AAK-2) and increases mitochondrial biogenesis. Consistent with the concept of...
Paper Details
Title
D-Glucosamine supplementation extends life span of nematodes and of ageing mice
Published Date
Apr 8, 2014
Journal
Volume
5
Issue
1
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