Original paper
Synthetic diversification of natural products: semi-synthesis and evaluation of triazole jadomycins
Abstract
Growth of Streptomyces venezuelae ISP5230 with O-propargyl-L-serine led to the efficient production of an alkyne-containing jadomycin. The installed alkyne functionality provided a uniquely reactive handle within the natural product and was subsequently reacted with a series of azides to afford an eight-member library of jadomycin triazoles. The compounds were evaluated for their DNA cleavage, antibacterial and cytotoxic...
Paper Details
Title
Synthetic diversification of natural products: semi-synthesis and evaluation of triazole jadomycins
Published Date
Jan 1, 2012
Journal
Volume
3
Issue
5
Pages
1640 - 1640
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Notes
History