Synthesis, Biological Evaluation, and Molecular Simulation of Chalcones and Aurones as Selective MAO‐B Inhibitors

A series of chalcones and aurones were synthesized and evaluated in vitro as monoamine oxidase inhibitors ( MAO i). Our results show that aurones, which had not been previously reported as MAO i, are MAO ‐B inhibitors. Thus, both families inhibited selectively the B isoform of MAO in the micromolar range, offering novel scaffolds for the design of new and potent MAO inhibitors. The main structural requirements for their activity were...