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Vitamin E, a Modifier of Platelet Function: Rationale and Use in Cardiovascular and Cerebrovascular Disease

Published on Apr 27, 2009in Nutrition Reviews 5.78
· DOI :10.1111/j.1753-4887.1999.tb06903.x
Manfred Steiner1
Estimated H-index: 1
Cite
Abstract
Vitamin E has emerged as a major factor in the prevention and inhibition of cardiovascular disease. The inhibition of platelet function, especially adhesion, which is an important event in the development and propagation of cardiovascular disease, plays a crucial role in the beneficial effect that vitamin E exerts on such diseases. Although it is best known for its antioxidant activity, vitamin E interferes with platelet adhesion via a mechanism that is independent of this action. Vitamin E-induced inhibition of protein kinase C leads to decreased platelet pseudopodia formation upon stimulation by agonists, a process that is instrumental in reducing platelet adhesion. In conjunction with potent inhibitors of platelet aggregation, vitamin E has become a widely applied treatment regimen for this group of diseases. Increased bleeding, especially when vitamin E is combined with a potent platelet aggregation inhibitor, has to be considered a side effect of its mechanism of action, but should not detract from the potential benefits for the majority of patients who take this vitamin.
  • References (31)
  • Citations (45)
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References31
Newest
Published on Jan 1, 1998in Annals of Medicine 3.05
K. Liede7
Estimated H-index: 7
(UH: University of Helsinki),
Jari Haukka54
Estimated H-index: 54
+ 1 AuthorsOp Heinonen32
Estimated H-index: 32
(UH: University of Helsinki)
α-tocopherol (vitamin E) may play a role in the treatment of arterial thromboembolic disease, possibly by inhibiting platelet aggregation. Thus far, no clinical evidence exists for this effect. The objective of this study was to assess the effect of α-tocopherol supplementation on gingival bleeding either in combination with acetylsalicylic acid (ASA) or without it. This study was an end-point examination of a random sample of male smokers who had participated in a controlled clinical trial, the...
Published on Sep 1, 1997in Journal of Cellular Physiology 4.52
Manfred Steiner5
Estimated H-index: 5
(ECU: East Carolina University),
Wei Li2
Estimated H-index: 2
(ECU: East Carolina University)
+ 2 AuthorsGeorge Sigounas17
Estimated H-index: 17
(ECU: East Carolina University)
Published on Mar 1, 1996in The Lancet 59.10
Ng Stephens3
Estimated H-index: 3
(University of Cambridge),
A Parsons4
Estimated H-index: 4
(University of Cambridge)
+ 4 AuthorsMj Mitchinson1
Estimated H-index: 1
(University of Cambridge)
Abstract Summary Background Vitamin E (α-tocopherol) is thought to have a role in prevention of atherosclerosis, through inhibition of oxidation of low-density lipoprotein. Some epidemiological studies have shown an association between high dietary intake or high serum concentrations of α-tocopherol and lower rates of ischaemic heart disease. We tested the hypothesis that treatment with a high dose of α-tocopherol would reduce subsequent risk of myocardial infarction (MI) and cardiovascular deat...
Published on Dec 1, 1995in The American Journal of Clinical Nutrition 6.57
Manfred Steiner5
Estimated H-index: 5
(Memorial Hospital of Rhode Island),
Michael Glantz40
Estimated H-index: 40
(Memorial Hospital of Rhode Island),
Andrew Lekos2
Estimated H-index: 2
(Memorial Hospital of Rhode Island)
One hundred patients with transient ischemic attacks, minor strokes, or residual ischemic neurologic deficits were enrolled in a double-blind, randomized study comparing the effects of aspirin plus vitamin E [0.4 g (400 IU)/d ; n = 52] with aspirin alone (325 mg ; n = 48). The patients received study medication for 2 y or until they reached a termination point. Preliminary results show a significant reduction in the incidence of ischemic events in patients in the vitamin E plus aspirin group com...
P Dowd1
Estimated H-index: 1
,
Z B Zheng1
Estimated H-index: 1
Abstract Vitamin E in the reduced, alpha-tocopherol form shows very modest anticlotting activity. By contrast, vitamin E quinone is a potent anticoagulant. This observation may have significance for field trials in which vitamin E is observed to exhibit beneficial effects on ischemic heart disease and stroke. Vitamin E quinone is a potent inhibitor of the vitamin K-dependent carboxylase that controls blood clotting. A newly discovered mechanism for the inhibition requires attachment of the activ...
Published on May 20, 1993in The New England Journal of Medicine 70.67
Eric B. Rimm166
Estimated H-index: 166
,
Meir J. Stampfer247
Estimated H-index: 247
+ 3 AuthorsBarry M. Popkin319
Estimated H-index: 319
Background The oxidative modification of low-density lipoproteins increases their incorporation into the arterial intima, an essential step in atherogenesis. Although dietary antioxidants, such as vitamin C, carotene, and vitamin E, have been hypothesized to prevent coronary heart disease, prospective epidemiologic data are sparse. Methods In 1986, 39,910 U.S. male health professionals 40 to 75 years of age who were free of diagnosed coronary heart disease, diabetes, and hypercholesterolemia com...
Published on May 20, 1993in The New England Journal of Medicine 70.67
Meir J. Stampfer247
Estimated H-index: 247
,
Charles H. Hennekens181
Estimated H-index: 181
+ 3 AuthorsBarry M. Popkin319
Estimated H-index: 319
Background Interest in the antioxidant vitamin E as a possible protective nutrient against coronary disease has intensified with the recognition that oxidized low-density lipoprotein may be involved in atherogenesis. Methods In 1980, 87,245 female nurses 34 to 59 years of age who were free of diagnosed cardiovascular disease and cancer completed dietary questionnaires that assessed their consumption of a wide range of nutrients, including vitamin E. During follow-up of up to eight years (679,485...
Published on Mar 1, 1993in Biochimica et Biophysica Acta 3.79
Eric Chatelain4
Estimated H-index: 4
(University of Bern),
Daniel Boscoboinik23
Estimated H-index: 23
(University of Bern)
+ 4 AuthorsAngelo Azzi60
Estimated H-index: 60
(University of Bern)
α-Tocopherol, the most active form of vitamin E, causes a dose-dependent inhibition of serum-induced proliferation of smooth muscle cells (A7r5) in culture. Some tocopherol-related compounds exhibiting various degrees of antioxidant potency have also been tested on cellular proliferation. No direct correlation between the antioxidant activity of these compounds and their effect on smooth muscle cell growth could be observed. While most of the derivatives employed were not effective in inhibiting...
Published on Jan 1, 1993in Thrombosis Research 3.27
Mark Geanacopoulos2
Estimated H-index: 2
(UVA: University of Virginia),
Joy Turner1
Estimated H-index: 1
(UVA: University of Virginia)
+ 2 AuthorsAdrian R. L. Gear22
Estimated H-index: 22
(UVA: University of Virginia)
Abstract The role of protein kinase C (PKC) in platelet activation by thrombin was assessed using a PKC inhibitor Ro 31-7549/001 (R 2 ) which, in vitro , shows more selectivity for PKC than other kinase inhibitors. During early (1.5 s) thrombin-induced platelet activation, when phosphorylation of 47 kDa protein (pleckstrin) and myosin light chain by PKC and myosin light chain kinase, respectively, are most readily differentiated, R 2 suppressed phosphorylation of pleckstrin more effectively than...
Cited By45
Newest
Published on Jan 8, 2019in Journal of the National Cancer Institute 10.21
Patricia A. Thompson33
Estimated H-index: 33
(SBU: Stony Brook University)
Published on Mar 1, 2015in Integrative Cancer Therapies 2.63
M. Robyn Andersen30
Estimated H-index: 30
(UW: University of Washington),
Erin Sweet7
Estimated H-index: 7
(Bastyr University)
+ 1 AuthorsLeanna J. Standish24
Estimated H-index: 24
(Bastyr University)
Objective. The use of complementary or alternative medicine has increased greatly over the last decade. This study describes a cross-sectional survey of women with breast cancer to describe their use of herbs and supplements that might have placed them at elevated risk for bleeding at the time of their primary treatment surgery for breast cancer. Methods. We present cross-sectional survey results from a cohort of 316 women with breast cancer. The participants included a convenience sample of 98 ...
Published on Jan 1, 2015in Oxidative Medicine and Cellular Longevity 4.87
Orn-uma Yanpanitch1
Estimated H-index: 1
,
Suneerat Hatairaktham5
Estimated H-index: 5
+ 5 AuthorsRuchaneekorn W. Kalpravidh9
Estimated H-index: 9
Studies on the antioxidant treatment for thalassemia have reported variable outcomes. However, treatment of thalassemia with a combination of hydrophobic and hydrophilic antioxidants and an iron chelator has not been studied. This study investigated the effects of antioxidant cocktails for the treatment of β-thalassemia/hemoglobin E (HbE), which is the most common form of β-thalassemia in Southeast Asia. Sixty patients were divided into two groups receiving N-acetylcysteine, deferiprone, and eit...
Published on Nov 1, 2014in Journal of the American Dental Association 2.57
Mark Donaldson11
Estimated H-index: 11
,
Riva Touger-Decker18
Estimated H-index: 18
ABSTRACT Background. Given the prevalence of vitamin and mineral supplement use among consumers and the potential for vitamin- and mineral-drug interactions, as well as oral and systemic adverse effects of excess consumption, oral health care providers (OHCPs) should ask all patients about their use. The challenges for OHCPs are how to recognize oral and systemic manifestations of these interactions and how to safely manage the care of these patients while avoiding potential interactions. Method...
Published on Jun 1, 2014in Journal of Physiology and Biochemistry 2.52
Jessié M. Gutierres20
Estimated H-index: 20
(UFSM: Universidade Federal de Santa Maria),
Fabiano B. Carvalho16
Estimated H-index: 16
(UFSM: Universidade Federal de Santa Maria)
+ 13 AuthorsJeandre Augusto dos Santos Jaques13
Estimated H-index: 13
(UFSM: Universidade Federal de Santa Maria)
The aim of this study was to assess whether α-tocopherol administration prevented alterations in the ectonucleotidase activities and platelet aggregation induced by high-fat diet in rats. Thus, we examined four groups of male rats which received standard diet, high-fat diet (HFD), α-tocopherol (α-Toc), and high-fat diet plus α-tocopherol. HFD was administered ad libitum and α-Toc by gavage using a dose of 50 mg/kg. After 3 months of treatment, animals were submitted to euthanasia, and blood samp...
Published on Aug 11, 2011in PLOS ONE 2.78
Awad A. Ahmed8
Estimated H-index: 8
(TU: Temple University),
Pekka Mooar5
Estimated H-index: 5
(TU: Temple University)
+ 2 AuthorsCurtis Miyamoto13
Estimated H-index: 13
(TU: Temple University)
Background Prolonged wound-discharge following total hip arthroplasty (THA) is associated with an increased risk of infection. However, the potential role of hypertension in prolonging the duration of wound healing in this population has not yet been investigated. The aim of the present study was to compare healing in this population that has not yet been investigated. The aim of the present study was to compare hypertensive and normotensive THA patients in terms of the length of time required t...
Published on Jan 1, 2010in Methods of Molecular Biology
Shaker A. Mousa56
Estimated H-index: 56
(Albany College of Pharmacy and Health Sciences)