UV SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF SITAGLIPTIN PHOSPHATE IN BULK AND TABLET DOSAGE FORM BY ABSORPTION RATIO AND AREA UNDER THE CURVE METHOD

To develop two simple UV spectrophotometric methods for simultaneous estimation of Sitagliptin phosphate (STG) in bulk and tablet dosage forms and validates as per ICH guidelines. Method A involved Absorbance maxima method which based on the measurement of absorbance at λ max of Sitagliptin phosphate 267 nm and Method B involved Area under the curve (AUC) method which based on the measurement of AUC in the range of 261 - 270 nm. The developed...