Expression of S100A8/A9 in HaCaT keratinocytes alters the rate of cell proliferation and differentiation
Abstract
S100A8/A9 promotes NADPH oxidase in HaCaT keratinocytes and subsequently increases NFκB activation, which plays important roles in the balance between epidermal growth and differentiation. S100A8/A9-positive HaCaT cells present with a significantly reduced rate of cell division and greater expression of two keratinocyte differentiation markers, involucrin and filaggrin, than control cells. S100A8/A9 mutants fail to enhance NFκB activation,...
Paper Details
Title
Expression of S100A8/A9 in HaCaT keratinocytes alters the rate of cell proliferation and differentiation
Published Date
Dec 28, 2010
Journal
Volume
585
Issue
2
Pages
440 - 446
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History