A Pharmacogenetics-based Approach to Reduce Cardiovascular Mortality with the Prophylactic Use of Statins

: Nitric oxide (NO) is the main endothelial‐derived relaxation factor and plays a major role in cardiovascular homeostasis. This key signalling molecule is synthesised by a family of nitric oxide synthases (NOS), and the endothelial isoform (eNOS) is the most important for nitric oxide formation in the cardiovascular system. Cardiovascular drugs including statins increase eNOS expression and up‐regulate NO formation, and this effect may be...