De novo DNA Methyltransferases Dnmt3a and Dnmt3b regulate the onset ofIgκlight chain rearrangement during early B-cell development
Abstract
Immunoglobulin genes V(D)J rearrangement during early lymphopoiesis is a critical process involving sequential recombination of the heavy and light chain loci. A number of transcription factors act together with temporally activated recombinases and chromatin accessibility changes to regulate this complex process. Here, we deleted the de novo DNA methyltransferases Dnmt3a and Dnmt3b in early B cells of conditionally targeted mice, and monitored...
Paper Details
Title
De novo DNA Methyltransferases Dnmt3a and Dnmt3b regulate the onset ofIgκlight chain rearrangement during early B-cell development
Published Date
Jun 16, 2015
Volume
45
Issue
8
Pages
2343 - 2355
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