Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation
Abstract
The balance between self-renewal and differentiation of adult stem cells is essential for tissue homeostasis. Here we show that in the haematopoietic system this process is governed by polycomb chromobox (Cbx) proteins. Cbx7 is specifically expressed in haematopoietic stem cells (HSCs), and its overexpression enhances self-renewal and induces leukaemia. This effect is dependent on integration into polycomb repressive complex-1 (PRC1) and...
Paper Details
Title
Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation
Published Date
Apr 1, 2013
Journal
Volume
15
Issue
4
Pages
353 - 362
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