Spatial and Temporal Mapping of De Novo Mutations in Schizophrenia to a Fetal Prefrontal Cortical Network

Cell64.50
Volume: 154, Issue: 3, Pages: 518 - 529
Published: Aug 1, 2013
Abstract
SUMMARY Genes disrupted in schizophrenia may be revealed by de novo mutations in affected persons from otherwise healthy families. Furthermore, during normal brain development, genes are expressed in patterns specifictodevelopmentalstageandneuroanatomical structure. Weidentified denovomutationsin persons with schizophrenia and then mapped the responsible genes onto transcriptome profiles of normal human brain tissues from age 13 weeks gestation...
Paper Details
Title
Spatial and Temporal Mapping of De Novo Mutations in Schizophrenia to a Fetal Prefrontal Cortical Network
Published Date
Aug 1, 2013
Journal
Volume
154
Issue
3
Pages
518 - 529
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