Systemic antithrombotic effects of ADAMTS13
Abstract
The metalloprotease ADAMTS13 (a disintegrin-like and metalloprotease with thrombospondin type I repeats 13) cleaves highly adhesive large von Willebrand factor (VWF) multimers after their release from the endothelium. ADAMTS13 deficiency is linked to a life-threatening disorder, thrombotic thrombocytopenic purpura (TTP), characterized by platelet-rich thrombi in the microvasculature. Here, we show spontaneous thrombus formation in activated...
Paper Details
Title
Systemic antithrombotic effects of ADAMTS13
Published Date
Mar 13, 2006
Volume
203
Issue
3
Pages
767 - 776
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