Combinatorial stress responses: direct coupling of two major stress responses in Escherichia coli

Combinatorial stress responses: direct coupling of two major stress responses in Escherichia coli – – The synthesis of (p)ppGpp in response to nutritional stresses has been studied for more than forty years. The regulatory basis by which (p)ppGpp levels are modulated by the (p)ppGpp synthetase RelA (product of relA gene) and the (p)ppGpp synthetase/hydrolase SpoT (product of spoT gene) in E. coli are well understood: upon amino acid starvation,...